Analysis of electronic health record data illuminates heterogeneity of pediatric allergic trajectories

Presentation Time: 05:30 PM - 07:00 PM

Abstract Keywords: Pediatrics, Bioinformatics, Phenomics and Phenome-wide Association Studies
Primary Track: Applications
Programmatic Theme: Clinical Research Informatics

We used longitudinal electronic health record data to develop a primary care-based birth cohort to study pediatric allergic disease trajectories. Focusing on atopic dermatitis, IgE-mediated food allergy, asthma, allergic rhinitis, and eosinophilic esophagitis, we identified heterogenous 2-to-5-step trajectories, including ones distinct from the classical allergic march sequence. Atopic dermatitis-to-asthma and atopic dermatitis-to-allergic rhinitis trajectories were enriched among Black and female children, respectively. Our study highlights a framework for nuanced study of health trajectories in children.

Speaker(s):
Stanislaw Gabryszewski, MD, PhD
Children's Hospital of Philadelphia & University of Pennsylvania